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颜德岳课题组代表性论文
发布日期:2012-1-1
 
1.       Wei Tao, Yong Liu, Binbin Jiang, Songrui Yu, Wei Huang, Yongfeng Zhou, Deyue Yan, A Linear-Hyperbranched Supramolecular Amphiphile and Its Self-Assembly into Vesicles with Great Ductility,

 
Figure 1 A linear-hyperbranched supramolecular amphiphile was synthesized through the noncovalent coupling of adamantane-functionalized long alkyl chain (AD-C18) and hyperbranched polyglycerol grafted from β-cyclodextrin (CD-g-HPG) by the specific AD/CD host-guest interactions. The obtained supramolecular Cn-b-HPGs self-assembled into unilamellar vesicles with great ductility that could be disassembled readily under a competitive host of β-CD.
 
图1长链烷基功能化的金刚烷(AD-C18)和接枝超支化聚缩水甘油的β-环糊精(CD-g-HPG)之间通过主-客体相互作用,经非共价偶合制备得到了线性-超支化两亲性超分子。该分子可以组装成柔性囊泡,并可在竞争性主体分子β-环糊精存在下实现解组装。
 
 
2.       Jinyao Liu, Wei Huang, Yan Pang, Ping Huang, Xinyuan Zhu, Yongfeng Zhou, Deyue Yan, Molecular Self-Assembly of A Homopolymer: An Alternative to Fabricate Drug Delivery Platform for Cancer Therapy, Angew. Chem. Int. Ed., 2011, 50, 9162 - 9166

 
Figure 2 The monomer 2-[(2-hydroxyethyl)-disulfanyl]ethoxy-2-oxo-1,3,2-dioxaphospholane can polymerize into a hyperbranched polyphosphate (HPHDP) through self-condensing ring-opening polymerization. HPHDP is an amphiphilic homopolymer with alternative hydrophobic disulfide and hydrophilic polyphosphate segments along the highly branched structure. It can self-assembly into fairly homogeneous micelles with redox-responsive property. These micelles can be used as smart drug carriers.
 
图2 单体2-[(2-羟乙基)-双硫]乙氧基-2-氧-1,3,2-二氧杂磷环戊烷经自缩合开环聚合制备得到超支化聚磷酸酯。该超支化聚合物的支化结构中含有疏水性的双硫单元和亲水性的磷酸酯单元,可以在水中自组装得到具有还原响应性的尺寸均一的胶束,可作为智能型药物载体使用。
 
3.       Haibao Jin, Yongli Zheng, Yong Liu, Haixing Cheng, Yongfeng Zhou, Deyue Yan, Reversible and Large-Scale Cytomimetic Vesicle Aggregation: Light-Responsive Host–Guest Interactions, Angew. Chem. Int. Ed., 2011, 50, 10352 – 10356

 
Figure 3 Two populations of BPs, one functionlized with β-cyclodextrin (CD-BPs) and the other with azobenzene (Azo-BPs), were prepared through a coassembly method. They then aggregated through multivalent intervesicular host-guest interactions between the CD and Azo groups. The vesicle aggregation process was not only highly efficient for obtaining large-scale macroscopic aggregates, but also totally reversible under alternating irradiation with UV and visible light.
 
 
图3 通过共组装的方法分别制备了β-环糊精和偶氮苯功能化的两类BP囊泡。通过环糊精和偶氮苯之间多重主客体相互作用实现两类囊泡的再聚集。这一组装过程不仅可以高效进行得到宏观聚集体,而且可以在紫外和可见光条件下实现完全可逆的组装和解组装转变。